منابع مشابه
Outlines of Enzyme Chemistry
lesions tend to have relatively large numbers of tubercle bacilli present, whereas others tend to have very few. However, the variations in the number of bacilli found in any one type of lesion is often so great that the average does not give a true picture of the situation. In one instance, for example, a series of 19 lesions were studied in which the bacterial content varied from 0 to 20,000 ...
متن کاملActivity-based protein profiling: from enzyme chemistry to proteomic chemistry.
Genome sequencing projects have provided researchers with a complete inventory of the predicted proteins produced by eukaryotic and prokaryotic organisms. Assignment of functions to these proteins represents one of the principal challenges for the field of proteomics. Activity-based protein profiling (ABPP) has emerged as a powerful chemical proteomic strategy to characterize enzyme function di...
متن کاملAn Introduction to Biological and Enzyme Chemistry
opportunity of keeping up the organic chemistry which they were required to study for their various degrees. The work opens with a preliminary chapter on .chemical action of living matter and proceeds with a description of ordinary bacteriological technique. Chapters 3 and 4, as already mentioned, are largely taken up with the organic chemistry and with a description of such bodies as sugars, e...
متن کاملChemistry of enzyme inhibitors of microbial origin.
Study of antibiotics has furnished interesting materials to chemistry of natural products. I initiated the screening study of enzyme inhibitors produced by microorganisms and isolated leupeptin and antipain inhibiting trypsin and papain, chymostatin inhibiting chymotrypsin, pepstatin inhibiting pepsin, panosialin inhibiting sialidases, oudenone inhibiting tyrosine hydroxylase, dopastin inhibiti...
متن کاملBivalent enzyme inhibitors discovered using dynamic covalent chemistry.
A bivalent dynamic covalent chemistry (DCC) system has been designed to selectively target members of the homodimeric glutathione-S-transferase (GST) enzyme family. The dynamic covalent libraries (DCLs) use aniline-catalysed acylhydrazone exchange between bivalent hydrazides and glutathione-conjugated aldehydes and the bis-hydrazides act as linkers to bridge between each glutathione binding sit...
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ژورنال
عنوان ژورنال: Nature
سال: 1958
ISSN: 0028-0836,1476-4687
DOI: 10.1038/181389a0